Photo by Skyy

Search Cape Girardeau hotels

Most accommodation are fully refundable. Because flexibility matters.

Save an average of 15% on thousands of hotels with Expedia Rewards

Search over 2.9 million properties and 550 airlines worldwide

Check Cape Girardeau hotel prices

Tomorrow night
This weekend
Next weekend

Filter by

Popular filters
Popular filters
Guest rating
Guest rating
Property class
Payment type
Payment type
Property type
Property type
Area
Area
Popular locations
Popular locations
Meal plans available
Meal plans available
Amenities
Amenities
Accessibility
Accessibility
Traveller experience
Traveller experience

Top hotels and accommodation in Cape Girardeau

Serenity South -- Gardens, River-Views, and Refreshing Space
10.0 out of 10, Exceptional, (113)
"Lovely house, well maintained and stocked. Nice bed linens and towels. Lots of thoughtful features like a coffee and tea station upstairs with the bedrooms. The host even left fresh cookies for us in the kitchen. Beautiful gardens with cut flowers. Fantastic location just blocks from shopping, restaurants and bars. Highly recommend."
The price is AU$375
per night
13 May - 14 May
Serenity South -- Gardens, River-Views, and Refreshing Space
Loft Apartment Across From Semo University Houch Field House. Walk To Events
10.0 out of 10, Exceptional, (69)
"Enjoyed this property very much. Great location. Very clean."
The price is AU$284
per night
23 May - 24 May
Loft Apartment Across From Semo University Houch Field House. Walk To Events
Charming Secluded Getaway Cabin within minutes of amenities
10.0 out of 10, Exceptional, (9)
"This place is amazing if what you want is relaxing. My wife and I stayed here for the total eclipse and did not see another person for our whole stay. This place sets the standard for secluded. The cabin had everything you could need for a great stay. Price was very reasonable. We could not be happier. "
Charming Secluded Getaway Cabin within minutes of amenities
Save an average of 15% on thousands of hotels when you're signed in
Newly Constructed Luxury Apartment - Sleeps 7
10.0 out of 10, Exceptional, (2)
"Clean, nice, right downtown."
Newly Constructed Luxury Apartment - Sleeps 7
Updated 3 bedroom unit with balcony!
10.0 out of 10, Exceptional, (1)
"Very nice place only downsize albeit cute is the claw foot tub with make shift shower, The unit worked very well for what we were looking for near SEMO campus"
Updated 3 bedroom unit with balcony!
Deer Run Creek: 5 Bed Home in Great Neighborhood
10.0 out of 10, Exceptional, (1)
"Very easy to book, communication was great, very clean and looked just as the pictures show"
Deer Run Creek: 5 Bed Home in Great Neighborhood
Historical 'Kage House' Short Term Rental located in "Old Town Cape"
10.0 out of 10, Exceptional, (202)
"beautiful place. great location. recommend to anyone"
Historical 'Kage House' Short Term Rental located in "Old Town Cape"
Cozy cabins on beautiful Horseshoe Lake
9.8 out of 10, Exceptional, (18)
"We were looking for a place to view the 2024 solar eclipse and we found this cabin, which was in the path of totality! We were so excited to be able to view the eclipse from the property, which meant that we didn't have to deal with traffic getting home or to other lodging. Sherry was a great host. The cabin was quiet and clean. and just perfect for a two-night stay. "
The price is AU$210
per night
3 May - 4 May
Cozy cabins on beautiful Horseshoe Lake
Artistic and Creative Vibe with Indoor Swing 2 Blocks to Downtown & near SEMO
9.8 out of 10, Exceptional, (17)
"Town was cute and ecclectic, stay at VRBO gave the same vibes. Very clean and fun. We only stayed for 1 night but would love to come back- stopped by Annie Laurie’s, Indie House, Kenny’s Flippin Burgers, Ebb and Flow brewery and Broadway Bistro/vintage store. We recommend all of them!"
The price is AU$230
per night
5 May - 6 May
Artistic and Creative Vibe with Indoor Swing 2 Blocks to Downtown & near SEMO
Drury Plaza Hotel Cape Girardeau Conference Center
3.0 star property
9.6 out of 10, Exceptional, (1001)
"Very friendly staff with very clean and nice rooms"
The price is AU$202
per night
19 May - 20 May
Drury Plaza Hotel Cape Girardeau Conference Center
Holiday Inn Express Hotel & Suites Cape Girardeau I-55, an IHG Hotel
2.5 star property
9.6 out of 10, Exceptional, (1002)
"Staff very friendly and helpful !"
The price is AU$204
per night
8 May - 9 May
Holiday Inn Express Hotel & Suites Cape Girardeau I-55, an IHG Hotel
Courtyard by Marriott Cape Girardeau Downtown
3.0 star property
9.6 out of 10, Exceptional, (337)
"A clean facility"
The price is AU$233
per night
26 May - 27 May
Courtyard by Marriott Cape Girardeau Downtown
Hampton Inn Cape Girardeau I 55 East
2.5 star property
9.6 out of 10, Exceptional, (617)
"Staff at Hampton Inn fixed Expedias attempts to cancel our reservation. Took over an hour of repeated calls and being hung up on by Expedia. YAY Hampton Inn. Without you, we would slept in our rental car as all hotels in town were booked due to the eclipse. BOO Expedia - we’ll never book with you again."
The price is AU$197
per night
19 May - 20 May
Hampton Inn Cape Girardeau I 55 East
Drury Inn & Suites Cape Girardeau
3.0 star property
9.4 out of 10, Exceptional, (772)
"Lots of places in waljing distance "
The price is AU$187
per night
7 May - 8 May
Drury Inn & Suites Cape Girardeau
4-acre Home with Multiple Decks: Pool Table | Putt-Putt I 4 miles to Downtown
9.2 out of 10, Wonderful, (20)
"This property was perfect for our family and our 4 boys really enjoyed the mini golf, pool table, couch swing and signing the wall. We will definitely be coming back on our travels. Unique decor and beautiful space! "
The price is AU$594
per night
6 May - 7 May
4-acre Home with Multiple Decks: Pool Table | Putt-Putt I 4 miles to Downtown
Pear Tree Inn Cape Girardeau West
2.5 star property
9.0 out of 10, Wonderful, (1001)
"clean and quiet!"
The price is AU$117
per night
2 June - 3 June
Pear Tree Inn Cape Girardeau West
Pear Tree Inn Cape Girardeau Near the Medical Center
2.5 star property
9.0 out of 10, Wonderful, (1001)
"Check is was extremely smooth. Room is great. Got to check in early. Christina ar the chech in desk was very helpful with our request."
The price is AU$117
per night
6 May - 7 May
Pear Tree Inn Cape Girardeau Near the Medical Center
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
2.5 star property
9.0 out of 10, Wonderful, (370)
"A nice, clean , quiet property. Very good buy"
The price is AU$149
per night
26 May - 27 May
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Auburn Place Hotel And Suites
2.5 star property
8.8 out of 10, Excellent, (1003)
"Accommodated my physical needs pleasantly. Clean appearance and smell. No glitches in app. "
The price is AU$117
per night
23 May - 24 May
Auburn Place Hotel And Suites
The Rested Duck Mallard Room
8.8 out of 10, Excellent, (13)
"Love this place and people!"
The price is AU$222
per night
3 May - 4 May
The Rested Duck Mallard Room
Don't see what you're looking for?
See all available properties in Cape Girardeau
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

More cheap accommodation in Cape Girardeau

Stay near top Cape Girardeau attractions

Cape Girardeau Travel Info

Number of reviews
4,986
Accommodation
157 hotels
Highest price
AU$594
Lowest price
AU$117
Reasons to visit
Hunter Valley Winery, Cape Splash Family Aquatic Centre and Lazy L Safari Park
Hotels with family-friendly amenities
9
Hotels with dining
8

Frequently asked questions

What's the best place to stay in Cape Girardeau?

Courtyard by Marriott Cape Girardeau Downtown is a favourite property for Expedia customers. This hotel is a short 6-minute walk from Mississippi River, and it offers a restaurant and free parking. Other favourite options based on traveller reviews include Hampton Inn Cape Girardeau I 55 East and Drury Inn & Suites Cape Girardeau. See all available top hotels, or vacation rentals in Cape Girardeau.

What are some of the best holiday rentals that Cape Girardeau has to offer?

Serenity South -- Gardens, River-Views, and Refreshing Space: This highly rated holiday home rental in Cape Girardeau is located on a river, and has a fireplace, a balcony and air conditioning to put you at ease in your new surroundings. It has 3 bedrooms, as well as a kitchen with a dishwasher, a fridge and a stovetop, so that you can cook with friends or family. Kick off your shoes and enjoy yourself with a garden and a selection of games. Other favourite homes for rent in Cape Girardeau are Little Blue Cottage on Spanish and Charming 2-Story- C.1847 - River Views - Fast Wifi. See all vacation rentals in Cape Girardeau.

If I need to cancel my hotel reservation in Cape Girardeau, will I receive a refund?

Yes! You'll find that most hotel reservations are refundable provided that you cancel prior to the accommodation's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If you booked a non-refundable reservation, you may still be able to cancel and be given a refund within a 24-hour period of booking. Filter your search by fully refundable to find flexible hotel deals in Cape Girardeau.

What's the best accommodation for a budget-friendly stay in Cape Girardeau?

Based on reviews, Auburn Place Hotel And Suites is a popular hotel for our travellers who want a more economical choice, and features free buffet breakfast and free WiFi. Other choices for your budget-friendly stay include Pear Tree Inn Cape Girardeau West and Pear Tree Inn Cape Girardeau Near the Medical Center. View all budget hotels in Cape Girardeau.

What's the best family accommodation in Cape Girardeau?

Pear Tree Inn Cape Girardeau West is a hotel with free parking and free continental breakfast, and it's a top choice on Expedia for families. Other good options for your family trip include Drury Plaza Hotel Cape Girardeau Conference Center and Pear Tree Inn Cape Girardeau Near the Medical Center. Also, attractions such as Cape Splash Family Aquatic Center and Cape Girardeau Conservation Nature Center are fun for children of all ages. Find more child-friendly accommodations in Cape Girardeau.

What's the best LGBTQ-friendly hotel in Cape Girardeau?

Pear Tree Inn Cape Girardeau West is a top LGBTQ-friendly hotel that features free breakfast and free Wi-Fi. Drury Inn & Suites Cape Girardeau and Drury Plaza Hotel Cape Girardeau Conference Center are other good options for your stay. See all available hotels listed as LGBTQ-friendly in Cape Girardeau.

What's the best dog-friendly hotel in Cape Girardeau?

Auburn Place Hotel And Suites is a top hotel for people travelling with their pets, and offers an indoor pool and a fitness centre for its human guests. Two other good options for you and your pet's trip include Pear Tree Inn Cape Girardeau West and Drury Inn & Suites Cape Girardeau. See more pet-friendly hotel accommodations in Cape Girardeau.

Where's the best place to stay in Cape Girardeau to be near historical sites?

Based on our travel expertise, Pear Tree Inn Cape Girardeau Near the Medical Center is a top hotel on Expedia for those interested in history, and it features free breakfast and free WiFi. See more options for historical stays in Cape Girardeau.

What are some accommodation options with pools in Cape Girardeau?

Drury Inn & Suites Cape Girardeau is a top hotel with a pool, free buffet breakfast and free WiFi. A couple of other options that offer an on-site pool include Pear Tree Inn Cape Girardeau Near the Medical Center and Holiday Inn Express Hotel & Suites Cape Girardeau I-55, an IHG Hotel. View all hotels with pools in Cape Girardeau.

What is the best spa hotel in Cape Girardeau?

Holiday Inn Express Hotel & Suites Cape Girardeau I-55, an IHG Hotel is a top spa hotel featuring a pool and a fitness centre. See all spa hotels in Cape Girardeau.

What is staying in Cape Girardeau like?

History buffs will enjoy exploring Cape Girardeau, and visitors give high marks for the top-notch restaurants. Tourists who journey to this welcoming city can discover its riverfront, university setting and shopping. In Cape Girardeau, there are 58 hotels and other accommodation options to choose from. Find out more about Cape Girardeau.

What should I do while I'm visiting Cape Girardeau?

Families come for attractions such as Cape Splash Family Aquatic Center, Cape Girardeau Conservation Nature Center and Lazy L Safari Park. Natural beauty is on display at Riverfront Bridge Park, Trail of Tears State Park and Shawnee National Forest. The university setting is a highlight and Southeast Missouri State University is worth a campus tour. Take a look at what more there is to see and do in Expedia's Cape Girardeau guide.